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Autophagy Deficiency in Macrophages Enhances NLRP3 Inflammasome Activity and Chronic Lung Disease Following Silica Exposure

Autophagy is an important metabolic mechanism that can promote cellular survival following injury. The specific contribution of autophagy to silica-induced inflammation and disease is not known. The objective of these studies was to determine the effects of silica exposure on the autophagic pathway...

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Bibliografiske detaljer
Udgivet i:Toxicol Appl Pharmacol
Main Authors: Jessop, Forrest, Hamilton, Raymond F., Rhoderick, Joseph F., Shaw, Pamela K, Holian, Andrij
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054752/
https://ncbi.nlm.nih.gov/pubmed/27594529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2016.08.029
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