HSP90 shapes the consequences of human genetic variation

HSP90 acts as a protein-folding buffer that shapes the manifestations of genetic variation in model organisms. Whether HSP90 influences the consequences of mutations in humans, potentially modifying the clinical course of genetic diseases, remains unknown. Mining data for >1,500 disease-causing m...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Karras, Georgios I., Yi, Song, Sahni, Nidhi, Fischer, Máté, Xie, Jenny, Vidal, Marc, D'Andrea, Alan D., Whitesell, Luke, Lindquist, Susan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325763/
https://ncbi.nlm.nih.gov/pubmed/28215707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.01.023
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