HSP90 shapes the consequences of human genetic variation

HSP90 acts as a protein-folding buffer that shapes the manifestations of genetic variation in model organisms. Whether HSP90 influences the consequences of mutations in humans, potentially modifying the clinical course of genetic diseases, remains unknown. Mining data for >1,500 disease-causing m...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Karras, Georgios I., Yi, Song, Sahni, Nidhi, Fischer, Máté, Xie, Jenny, Vidal, Marc, D'Andrea, Alan D., Whitesell, Luke, Lindquist, Susan
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325763/
https://ncbi.nlm.nih.gov/pubmed/28215707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.01.023
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