Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes

To characterize the mutational patterns of acute lymphoblastic leukemia (ALL) we performed deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse samples from 172 pediatric ALL patients. We found an overall greater mutational burden and more driver mutations in T-cell A...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Lindqvist, C. Mårten, Lundmark, Anders, Nordlund, Jessica, Freyhult, Eva, Ekman, Diana, Almlöf, Jonas Carlsson, Raine, Amanda, Övernäs, Elin, Abrahamsson, Jonas, Frost, Britt-Marie, Grandér, Dan, Heyman, Mats, Palle, Josefine, Forestier, Erik, Lönnerholm, Gudmar, Berglund, Eva C., Syvänen, Ann-Christine
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325426/
https://ncbi.nlm.nih.gov/pubmed/27590521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11773
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