Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles

BACKGROUND: Structural chromosomal rearrangements that lead to expressed fusion genes are a hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed transcriptome sequencing of 134 primary ALL patient samples to comprehensively detect fusion transcripts. METHODS: We combined fusio...

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Bibliografiska uppgifter
I publikationen:J Hematol Oncol
Huvudupphovsmän: Marincevic-Zuniga, Yanara, Dahlberg, Johan, Nilsson, Sara, Raine, Amanda, Nystedt, Sara, Lindqvist, Carl Mårten, Berglund, Eva C., Abrahamsson, Jonas, Cavelier, Lucia, Forestier, Erik, Heyman, Mats, Lönnerholm, Gudmar, Nordlund, Jessica, Syvänen, Ann-Christine
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2017
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557398/
https://ncbi.nlm.nih.gov/pubmed/28806978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0515-y
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