Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes

To characterize the mutational patterns of acute lymphoblastic leukemia (ALL) we performed deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse samples from 172 pediatric ALL patients. We found an overall greater mutational burden and more driver mutations in T-cell A...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Oncotarget
मुख्य लेखकों: Lindqvist, C. Mårten, Lundmark, Anders, Nordlund, Jessica, Freyhult, Eva, Ekman, Diana, Almlöf, Jonas Carlsson, Raine, Amanda, Övernäs, Elin, Abrahamsson, Jonas, Frost, Britt-Marie, Grandér, Dan, Heyman, Mats, Palle, Josefine, Forestier, Erik, Lönnerholm, Gudmar, Berglund, Eva C., Syvänen, Ann-Christine
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Impact Journals LLC 2016
विषय:
Research Paper
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325426/
https://ncbi.nlm.nih.gov/pubmed/27590521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11773
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