Refined detection and phasing of structural aberrations in pediatric acute lymphoblastic leukemia by linked-read whole-genome sequencing

Structural chromosomal rearrangements that can lead to in-frame gene-fusions are a leading source of information for diagnosis, risk stratification, and prognosis in pediatric acute lymphoblastic leukemia (ALL). Traditional methods such as karyotyping and FISH struggle to accurately identify and pha...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Nordlund, Jessica, Marincevic-Zuniga, Yanara, Cavelier, Lucia, Raine, Amanda, Martin, Tom, Lundmark, Anders, Abrahamsson, Jonas, Norén-Nyström, Ulrika, Lönnerholm, Gudmar, Syvänen, Ann-Christine
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018692/
https://ncbi.nlm.nih.gov/pubmed/32054878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59214-w
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