γ-secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets

As high-risk neuroblastoma (NB) has a poor prognosis, new therapeutic modalities are needed. We therefore investigated the susceptibility of NB cells to γ-secretase inhibitor I (GSI-I). NOTCH signaling activity, the cellular effects of GSI-I and its mechanisms of cytotoxicity were evaluated in NB ce...

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Pubblicato in:Oncotarget
Autori principali: Dorneburg, Carmen, Goß, Annika V., Fischer, Matthias, Roels, Frederik, Barth, Thomas F.E., Berthold, Frank, Kappler, Roland, Oswald, Franz, Siveke, Jens T., Molenaar, Jan J., Debatin, Klaus-Michael, Beltinger, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Priority Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325329/
https://ncbi.nlm.nih.gov/pubmed/27588497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11715
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