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Notch versus the proteasome: what is the target of γ-secretase inhibitor-I?
γ-Secretase inhibitors are new anti-cancer agents targeting Notch signaling. Their specificity for Notch is as yet unclear. Han and colleagues investigated the effects of Z-LeuLeuNleu-CHO on growth of breast cancer cells. The results demonstrated a reduction in cell viability primarily via proteasom...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790851/ https://ncbi.nlm.nih.gov/pubmed/19849815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2407 |
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