Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes

Genetic variation drives phenotypic diversity and influences the predisposition to metabolic disease. Here, we characterize the metabolic phenotypes of eight genetically distinct inbred mouse strains in response to a high-fat/high-sucrose diet. We found significant variation in diabetes-related phen...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kreznar, Julia H., Keller, Mark P., Traeger, Lindsay L., Rabaglia, Mary E., Schueler, Kathryn L., Stapleton, Donald S., Zhao, Wen, Vivas, Eugenio I., Yandell, Brian S., Broman, Aimee Teo, Hagenbuch, Bruno, Attie, Alan D., Rey, Federico E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325228/
https://ncbi.nlm.nih.gov/pubmed/28199845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.062
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