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Chemoproteomic profiling and discovery of protein electrophiles in human cells

Activity-based protein profiling (ABPP) serves as a chemical proteomic platform to discover and characterize functional amino acids in proteins on the basis of their enhanced reactivity towards small-molecule probes. This approach, to date, has mainly targeted nucleophilic functional groups, such as...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Matthews, Megan L, He, Lin, Horning, Benjamin D, Olson, Erika J, Correia, Bruno E, Yates, John R, Dawson, Philip E, Cravatt, Benjamin F
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325178/
https://ncbi.nlm.nih.gov/pubmed/28221344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2645
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