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Diastereoselective Organocatalytic Addition of α-Angelica Lactone to β-Halo-α-Ketoesters

A quinidine-catalyzed diastereoselective addition of α-angelica lactone to β-halo-α-ketoesters is reported. The α-angelica lactone displays unusual regioselectivity in this reaction, acting as a nucleophile at the α-position to provide fully substituted glycolic esters with three contiguous stereoce...

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Bibliografske podrobnosti
izdano v:J Org Chem
Main Authors: Griswold, Jessica A., Horwitz, Matthew A., Leiva, Leslie V., Johnson, Jeffrey S.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324730/
https://ncbi.nlm.nih.gov/pubmed/28164699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.6b03059
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