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Towards an asymmetric organocatalytic α-cyanation of β-ketoesters

This communication describes the first proof of concept for an asymmetric α-cyanation of β-ketoesters using a hypervalent iodine-based electrophilic cyanide-transfer reagent. A series of different organocatalysts has been investigated and it was found that the use of naturally occurring Cinchona alk...

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Detalhes bibliográficos
Publicado no:Tetrahedron Lett
Main Authors: Chowdhury, Raghunath, Schörgenhumer, Johannes, Novacek, Johanna, Waser, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366011/
https://ncbi.nlm.nih.gov/pubmed/25843983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.02.116
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