Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy

The microtubule-associated protein tau is implicated in various neurodegenerative diseases including Alzheimer’s disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. Mutations in the tau gene MAPT cau...

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Pubblicato in:Sci Rep
Autori principali: Wobst, Heike J., Denk, Franziska, Oliver, Peter L., Livieratos, Achilleas, Taylor, Tonya N., Knudsen, Maria H., Bengoa-Vergniory, Nora, Bannerman, David, Wade-Martins, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324134/
https://ncbi.nlm.nih.gov/pubmed/28233851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43198
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