Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau(−/−) mice

Microtubule associated protein tau (MAPT) is involved in the pathogenesis of Alzheimer's disease and many forms of frontotemporal dementia (FTD). We recently reported that Aβ-mediated inhibition of hippocampal long-term potentiation (LTP) in mice requires tau. Here, we asked whether expression...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Vargas-Caballero, Mariana, Denk, Franziska, Wobst, Heike J., Arch, Emily, Pegasiou, Chrysia-Maria, Oliver, Peter L., Shipton, Olivia A., Paulsen, Ole, Wade-Martins, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401872/
https://ncbi.nlm.nih.gov/pubmed/28484365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00201
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