Impact of Genetic Variation on Human CaMKK2 Regulation by Ca(2+)-Calmodulin and Multisite Phosphorylation

The Ca(2+)-calmodulin dependent protein kinase kinase-2 (CaMKK2) is a key regulator of neuronal function and whole-body energy metabolism. Elevated CaMKK2 activity is strongly associated with prostate and hepatic cancers, whereas reduced CaMKK2 activity has been linked to schizophrenia and bipolar d...

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Published in:Sci Rep
Main Authors: O’Brien, Matthew T., Oakhill, Jonathan S., Ling, Naomi X. Y., Langendorf, Christopher G., Hoque, Ashfaqul, Dite, Toby A., Means, Anthony R., Kemp, Bruce E., Scott, John W.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322397/
https://ncbi.nlm.nih.gov/pubmed/28230171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43264
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