Cathepsin K deficiency ameliorates systemic lupus erythematosus-like manifestations in Fas(lpr) mice

Cysteinyl cathepsin K (CatK) is expressed in osteoclasts to mediate bone resorption, but it is also inducible under inflammatory conditions. Fas(lpr) mice on a C57BL/6 background develop spontaneous systemic lupus erythematosus (SLE)-like manifestations. While normal mouse kidneys expressed negligib...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Zhou, Yi, Chen, Huimei, Liu, Li, Yu, Xueqing, Sukhova, Galina K., Yang, Min, Kyttaris, Vasileios C., Stillman, Isaac E., Gelb, Bruce, Libby, Peter, Tsokos, George, Shi, Guo-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321845/
https://ncbi.nlm.nih.gov/pubmed/28093526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501145
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