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Return to quiescence of murine neural stem cells by degradation of a pro-activation protein
Quiescence is essential for long-term maintenance of adult stem cells. Niche signals regulate the transit of stem cells from dormant to activated states. Here we show that the E3-ubiquitin ligase Huwe1 (HECT, UBA and WWE domain containing 1) is required for proliferating stem cells of the adult mous...
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| Publicat a: | Science |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321528/ https://ncbi.nlm.nih.gov/pubmed/27418510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf4802 |
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