ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

Chikungunya virus (CHIKV), an Old World alphavirus, is transmitted to humans by infected mosquitoes and causes acute rash and arthritis, occasionally complicated by neurologic disease and chronic arthritis. One determinant of alphavirus virulence is nonstructural protein 3 (nsP3) that contains a hig...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: McPherson, Robert Lyle, Abraham, Rachy, Sreekumar, Easwaran, Ong, Shao-En, Cheng, Shang-Jung, Baxter, Victoria K., Kistemaker, Hans A. V., Filippov, Dmitri V., Griffin, Diane E., Leung, Anthony K. L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321000/
https://ncbi.nlm.nih.gov/pubmed/28143925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621485114
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