ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

Chikungunya virus (CHIKV), an Old World alphavirus, is transmitted to humans by infected mosquitoes and causes acute rash and arthritis, occasionally complicated by neurologic disease and chronic arthritis. One determinant of alphavirus virulence is nonstructural protein 3 (nsP3) that contains a hig...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: McPherson, Robert Lyle, Abraham, Rachy, Sreekumar, Easwaran, Ong, Shao-En, Cheng, Shang-Jung, Baxter, Victoria K., Kistemaker, Hans A. V., Filippov, Dmitri V., Griffin, Diane E., Leung, Anthony K. L.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321000/
https://ncbi.nlm.nih.gov/pubmed/28143925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621485114
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