ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

Chikungunya virus (CHIKV), an Old World alphavirus, is transmitted to humans by infected mosquitoes and causes acute rash and arthritis, occasionally complicated by neurologic disease and chronic arthritis. One determinant of alphavirus virulence is nonstructural protein 3 (nsP3) that contains a hig...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: McPherson, Robert Lyle, Abraham, Rachy, Sreekumar, Easwaran, Ong, Shao-En, Cheng, Shang-Jung, Baxter, Victoria K., Kistemaker, Hans A. V., Filippov, Dmitri V., Griffin, Diane E., Leung, Anthony K. L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321000/
https://ncbi.nlm.nih.gov/pubmed/28143925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621485114
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