ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Alphaviruses are plus-strand RNA viruses that cause encephalitis, rash, and arthritis. The nonstructural protein (nsP) precursor polyprotein is translated from genomic RNA and processed into four nsPs. nsP3 has a highly conserved macrodomain (MD) that binds ADP-ribose (ADPr), which can be conjugated...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Abraham, Rachy, Hauer, Debra, McPherson, Robert Lyle, Utt, Age, Kirby, Ilsa T., Cohen, Michael S., Merits, Andres, Leung, Anthony K. L., Griffin, Diane E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217424/
https://ncbi.nlm.nih.gov/pubmed/30322911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812130115
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