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The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases

Human pathogenic positive single strand RNA ((+)ssRNA) viruses, including Chikungunya virus, pose severe health problems as for many neither efficient vaccines nor therapeutic strategies exist. To interfere with propagation, viral enzymatic activities are considered potential targets. Here we addres...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Eckei, Laura, Krieg, Sarah, Bütepage, Mareike, Lehmann, Anne, Gross, Annika, Lippok, Barbara, Grimm, Alexander R., Kümmerer, Beate M., Rossetti, Giulia, Lüscher, Bernhard, Verheugd, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288732/
https://ncbi.nlm.nih.gov/pubmed/28150709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41746
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