The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-like-CoVs encode 3 tandem macrodomains within non-structural protein 3 (nsp3). The first macrodomain, Mac1, is conserved throughout CoVs, and binds to and hydrolyzes mono-ADP-ribose (MAR) from target proteins. Mac1 likely co...

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Udgivet i:bioRxiv
Main Authors: Alhammad, Yousef M.O., Kashipathy, Maithri M., Roy, Anuradha, Gagné, Jean-Philippe, McDonald, Peter, Gao, Philip, Nonfoux, Louis, Battaile, Kevin P., Johnson, David K., Holmstrom, Erik D., Poirier, Guy G., Lovell, Scott, Fehr, Anthony R.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263559/
https://ncbi.nlm.nih.gov/pubmed/32511412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.05.11.089375
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