The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-related CoVs encode 3 tandem macrodomains within nonstructural protein 3 (nsp3). The first macrodomain, Mac1, is conserved throughout CoVs and binds to and hydrolyzes mono-ADP-ribose (MAR) from target proteins. Mac1 likely c...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Alhammad, Yousef M. O., Kashipathy, Maithri M., Roy, Anuradha, Gagné, Jean-Philippe, McDonald, Peter, Gao, Philip, Nonfoux, Louis, Battaile, Kevin P., Johnson, David K., Holmstrom, Erik D., Poirier, Guy G., Lovell, Scott, Fehr, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925111/
https://ncbi.nlm.nih.gov/pubmed/33158944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01969-20
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