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Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations

Glycogen synthase kinase-3 (GSK-3) is a multitasking serine/threonine protein kinase, which is associated with the pathophysiology of several diseases such as diabetes, cancer, psychiatric and neurodegenerative diseases. Tideglusib is a potent, selective, and irreversible GSK-3 inhibitor that has be...

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Bibliografiske detaljer
Udgivet i:Bioinformation
Main Authors: Chauhan, Navneet, Gajjar, Anuradha, Basha, Syed Hussain
Format: Artigo
Sprog:Inglês
Udgivet: Biomedical Informatics 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320924/
https://ncbi.nlm.nih.gov/pubmed/28293069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630012391
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