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Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations

Src plays a crucial role in many signaling pathways and contributes to a variety of cancers. Therefore, Src has long been considered an attractive drug target in oncology. However, the development of Src inhibitors with selectivity and novelty has been challenging. In the present study, pharmacophor...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Zhang, Yi, Zhang, Ting-jian, Tu, Shun, Zhang, Zhen-hao, Meng, Fan-hao
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571137/
https://ncbi.nlm.nih.gov/pubmed/32911607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25184094
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