Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate or inhibit NFκB-mediated gene expression influencing cellular fate. We studied the effect of hydrogen peroxide (H(2)O(2))-mediated oxidative stress and NFκB...

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Bibliographic Details
Published in:PLoS One
Main Authors: Song, Chunjuan, Mitter, Sayak K., Qi, Xiaoping, Beli, Eleni, Rao, Haripriya V., Ding, Jindong, Ip, Colin S., Gu, Hongmei, Akin, Debra, Dunn, William A., Bowes Rickman, Catherine, Lewin, Alfred S., Grant, Maria B., Boulton, Michael E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319799/
https://ncbi.nlm.nih.gov/pubmed/28222108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171940
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