The 5HT(1a) Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium

Age-related macular degeneration (AMD), a major cause of blindness in the elderly, is associated with oxidative stress, lipofuscin accumulation and retinal degeneration. The aim of this study was to determine if a 5-HT(1A) receptor agonist can reduce lipofuscin accumulation, reduce oxidative damage...

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Detalhes bibliográficos
Main Authors: Thampi, Prajitha, Rao, Haripriya Vittal, Mitter, Sayak K., Cai, Jun, Mao, Haoyu, Li, Hong, Seo, Soojung, Qi, Xiaoping, Lewin, Alfred S., Romano, Carl, Boulton, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317995/
https://ncbi.nlm.nih.gov/pubmed/22509307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034468
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