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Zinc Deficiency Leads to Lipofuscin Accumulation in the Retinal Pigment Epithelium of Pigmented Rats

BACKGROUND: Age-related macular degeneration (AMD) is associated with lipofuscin accumulation whereas the content of melanosomes decreases. Melanosomes are the main storage of zinc in the pigmented tissues. Since the elderly population, as the most affected group for AMD, is prone to zinc deficit, w...

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Detalhes bibliográficos
Main Authors: Julien, Sylvie, Biesemeier, Antje, Kokkinou, Despina, Eibl, Oliver, Schraermeyer, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245262/
https://ncbi.nlm.nih.gov/pubmed/22216222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029245
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