Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress

BACKGROUND: Stargardt disease (SD) is characterized by the accumulation of the age-pigment lipofuscin in the retinal pigment epithelium (RPE) and subsequent neuroretinal degeneration. The disease leads to vision loss early in life. Here, we investigate age-dependent ultrastructural changes in three...

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Dettagli Bibliografici
Pubblicato in:PeerJ
Autori principali: Taubitz, Tatjana, Tschulakow, Alexander V., Tikhonovich, Marina, Illing, Barbara, Fang, Yuan, Biesemeier, Antje, Julien-Schraermeyer, Sylvie, Schraermeyer, Ulrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: PeerJ Inc. 2018
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054867/
https://ncbi.nlm.nih.gov/pubmed/30038866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.5215
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