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Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

Autophagy, a lysosomal degradation pathway, plays crucial roles in health and disease. p62/SQSTM1 (hereafter p62) is an autophagy adaptor protein that can shuttle ubiquitinated cargo for autophagic degradation. Here, we show that upregulating the Drosophila p62 homolog ref(2)P/dp62, starting in midl...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Aparicio, Ricardo, Rana, Anil, Walker, David W.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688777/
https://ncbi.nlm.nih.gov/pubmed/31340141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.070
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