Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets f...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Michels, Aaron W., Landry, Laurie G., McDaniel, Kristen A., Yu, Liping, Campbell-Thompson, Martha, Kwok, William W., Jones, Kenneth L., Gottlieb, Peter A., Kappler, John W., Tang, Qizhi, Roep, Bart O., Atkinson, Mark A., Mathews, Clayton E., Nakayama, Maki
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319719/
https://ncbi.nlm.nih.gov/pubmed/27920090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1025
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