Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors

Proinsulin is an abundant protein that is selectively expressed by pancreatic beta cells and has been a focus for development of antigen-specific immunotherapies for type 1 diabetes (T1D). In this study, we sought to comprehensively evaluate reactivity to preproinsulin by CD4 T cells originally isol...

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Pubblicato in:Front Endocrinol (Lausanne)
Autori principali: Landry, Laurie G., Anderson, Amanda M., Russ, Holger A., Yu, Liping, Kent, Sally C., Atkinson, Mark A., Mathews, Clayton E., Michels, Aaron W., Nakayama, Maki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Endocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027116/
https://ncbi.nlm.nih.gov/pubmed/33841327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2021.622647
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