Bioreductively Activatable Prodrug Conjugates of Phenstatin Designed to Target Tumor Hypoxia

A variety of solid tumor cancers contain significant regions of hypoxia, which provide unique challenges for targeting by potent anticancer agents. Bioreductively activatable prodrug conjugates (BAPCs) represent a promising strategy for therapeutic intervention. BAPCs are designed to be biologically...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Winn, Blake A., Shi, Zhe, Carlson, Graham J., Wang, Yifan, Nguyen, Benson L., Kelly, Evan M., Ross, R. David, Hamel, Ernest, Chaplin, David J., Trawick, Mary L., Pinney, Kevin G.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319644/
https://ncbi.nlm.nih.gov/pubmed/28007448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.11.093
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