1,3-Butadiene-Induced Mitochondrial Dysfunction is Correlated with Mitochondrial CYP2E1 Activity in Collaborative Cross Mice

Cytochrome P450 2E1 (CYP2E1) metabolizes low molecular weight hydrophobic compounds, including 1,3-butadiene, which is converted by CYP2E1 to electrophilic epoxide metabolites that covalently modify cellular proteins and DNA. Previous CYP2E1 studies have mainly focused on the enzyme localized in the...

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Bibliographic Details
Published in:Toxicology
Main Authors: Hartman, Jessica H., Miller, Grover P., Caro, Andres A., Byrum, Stephanie D., Orr, Lisa M., Mackintosh, Samuel G., Tackett, Alan J., MacMillan-Crow, Lee Ann, Hallberg, Lance M., Ameredes, Bill T., Boysen, Gunnar
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319481/
https://ncbi.nlm.nih.gov/pubmed/28082109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2017.01.005
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