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Inhibitory Potency of 4-Carbon Alkanes and Alkenes toward CYP2E1 Activity
CYP2E1 has been implicated in the bioactivation of many small molecules into reactive metabolites which form adducts with proteins and DNA, and thus a better understanding of the molecular determinants of its selectivity are critical for accurate toxicological predictions. In this study, we determin...
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| Publicado no: | Toxicology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747242/ https://ncbi.nlm.nih.gov/pubmed/24561005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2014.02.003 |
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