Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III

Enhanced mitochondrial stability and decreased dependence on oxidative phosphorylation confer an acquired resistance to apoptosis in cancer cells, but may present opportunities for therapeutic intervention. The compound pancratistatin (PST) has been shown to selectively induce apoptosis in cancer ce...

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Publicado en:Sci Rep
Main Authors: Ma, Dennis, Pignanelli, Christopher, Tarade, Daniel, Gilbert, Tyler, Noel, Megan, Mansour, Fadi, Adams, Scott, Dowhayko, Alexander, Stokes, Kyle, Vshyvenko, Sergey, Hudlicky, Tomas, McNulty, James, Pandey, Siyaram
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318952/
https://ncbi.nlm.nih.gov/pubmed/28220885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42957
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