Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III

Enhanced mitochondrial stability and decreased dependence on oxidative phosphorylation confer an acquired resistance to apoptosis in cancer cells, but may present opportunities for therapeutic intervention. The compound pancratistatin (PST) has been shown to selectively induce apoptosis in cancer ce...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ma, Dennis, Pignanelli, Christopher, Tarade, Daniel, Gilbert, Tyler, Noel, Megan, Mansour, Fadi, Adams, Scott, Dowhayko, Alexander, Stokes, Kyle, Vshyvenko, Sergey, Hudlicky, Tomas, McNulty, James, Pandey, Siyaram
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318952/
https://ncbi.nlm.nih.gov/pubmed/28220885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42957
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