The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition

The transcription factor Snail is a master regulator of cellular identity and epithelial-to-mesenchymal transition (EMT) directly repressing a broad repertoire of epithelial genes. How chromatin modifiers instrumental to its activity are recruited to Snail-specific binding sites is unclear. Here we...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Battistelli, C, Cicchini, C, Santangelo, L, Tramontano, A, Grassi, L, Gonzalez, F J, de Nonno, V, Grassi, G, Amicone, L, Tripodi, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318668/
https://ncbi.nlm.nih.gov/pubmed/27452518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.260
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