An Endosomal NAADP-Sensitive Two-Pore Ca(2+) Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca(2+) derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic reticulum (ER). Antagonizing action of the...

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Bibliografische gegevens
Gepubliceerd in:Cell Rep
Hoofdauteurs: Kilpatrick, Bethan S., Eden, Emily R., Hockey, Leanne N., Yates, Elizabeth, Futter, Clare E., Patel, Sandip
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2017
Onderwerpen:
Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318655/
https://ncbi.nlm.nih.gov/pubmed/28199837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.052
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