An Endosomal NAADP-Sensitive Two-Pore Ca(2+) Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca(2+) derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic reticulum (ER). Antagonizing action of the...

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Udgivet i:Cell Rep
Main Authors: Kilpatrick, Bethan S., Eden, Emily R., Hockey, Leanne N., Yates, Elizabeth, Futter, Clare E., Patel, Sandip
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2017
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318655/
https://ncbi.nlm.nih.gov/pubmed/28199837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.052
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