Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies

OBJECTIVES: Designing studies with an internal pilot phase may optimise the use of pilot work to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed decision or ‘progression’ criteria at the juncture between the internal pilot and main trial phases provides a va...

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Опубликовано в: :BMJ Open
Главные авторы: Avery, Kerry N L, Williamson, Paula R, Gamble, Carrol, O'Connell Francischetto, Elaine, Metcalfe, Chris, Davidson, Peter, Williams, Hywel, Blazeby, Jane M
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2017
Предметы:
Health Services Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318608/
https://ncbi.nlm.nih.gov/pubmed/28213598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2016-013537
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