Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies

OBJECTIVES: Designing studies with an internal pilot phase may optimise the use of pilot work to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed decision or ‘progression’ criteria at the juncture between the internal pilot and main trial phases provides a va...

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Bibliographische Detailangaben
Veröffentlicht in:BMJ Open
Hauptverfasser: Avery, Kerry N L, Williamson, Paula R, Gamble, Carrol, O'Connell Francischetto, Elaine, Metcalfe, Chris, Davidson, Peter, Williams, Hywel, Blazeby, Jane M
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2017
Schlagworte:
Health Services Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318608/
https://ncbi.nlm.nih.gov/pubmed/28213598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2016-013537
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