Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies

OBJECTIVES: Designing studies with an internal pilot phase may optimise the use of pilot work to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed decision or ‘progression’ criteria at the juncture between the internal pilot and main trial phases provides a va...

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Bibliographic Details
Published in:BMJ Open
Main Authors: Avery, Kerry N L, Williamson, Paula R, Gamble, Carrol, O'Connell Francischetto, Elaine, Metcalfe, Chris, Davidson, Peter, Williams, Hywel, Blazeby, Jane M
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2017
Subjects:
Health Services Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318608/
https://ncbi.nlm.nih.gov/pubmed/28213598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2016-013537
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