Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.

Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ealick, S E, Babu, Y S, Bugg, C E, Erion, M D, Guida, W C, Montgomery, J A, Secrist, J A
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC53171/
https://ncbi.nlm.nih.gov/pubmed/1763067
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados