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Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.

Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one th...

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Bibliografiske detaljer
Main Authors: Ealick, S E, Babu, Y S, Bugg, C E, Erion, M D, Guida, W C, Montgomery, J A, Secrist, J A
Format: Artigo
Sprog:Inglês
Udgivet: 1991
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC53171/
https://ncbi.nlm.nih.gov/pubmed/1763067
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