Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one th...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1991
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53171/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1763067/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.24.11540 |
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