Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.

Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one th...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ealick, S E, Babu, Y S, Bugg, C E, Erion, M D, Guida, W C, Montgomery, J A, Secrist, J A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53171/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1763067/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.24.11540
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