Prospective Analysis in GIST Patients on the Role of Alpha-1 Acid Glycoprotein in Imatinib Exposure

BACKGROUND: For imatinib, a relationship between systemic exposure and clinical outcome has been suggested. Importantly, imatinib concentrations are not stable and decrease over time, for which several mechanisms have been suggested. In this study, we investigated if a decrease in alpha-1 acid glyco...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacokinet
Main Authors: Bins, Sander, Eechoute, Karel, Kloth, Jacqueline S. L., de Man, Femke M., Oosten, Astrid W., de Bruijn, Peter, Sleijfer, Stefan, Mathijssen, Ron H. J.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2016
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315737/
https://ncbi.nlm.nih.gov/pubmed/27461250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0441-0
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