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Prospective Analysis in GIST Patients on the Role of Alpha-1 Acid Glycoprotein in Imatinib Exposure

BACKGROUND: For imatinib, a relationship between systemic exposure and clinical outcome has been suggested. Importantly, imatinib concentrations are not stable and decrease over time, for which several mechanisms have been suggested. In this study, we investigated if a decrease in alpha-1 acid glyco...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Bins, Sander, Eechoute, Karel, Kloth, Jacqueline S. L., de Man, Femke M., Oosten, Astrid W., de Bruijn, Peter, Sleijfer, Stefan, Mathijssen, Ron H. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315737/
https://ncbi.nlm.nih.gov/pubmed/27461250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0441-0
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