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Pharmacokinetics of conivaptan use in patients with severe hepatic impairment

PURPOSE: Conivaptan is an intravenous dual V(1A)/V(2) vasopressin antagonist approved for the treatment of euvolemic and hypervolemic hyponatremia. Earlier studies showed that patients with moderate liver disease could be safely treated with conivaptan by reducing the dose by 50%, whereas patients w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Marbury, Thomas, Fox, Jerry, Kaelin, Byron, Pavliv, Leo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315214/
https://ncbi.nlm.nih.gov/pubmed/28243060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S125459
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