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Pharmacokinetics of conivaptan use in patients with severe hepatic impairment

PURPOSE: Conivaptan is an intravenous dual V(1A)/V(2) vasopressin antagonist approved for the treatment of euvolemic and hypervolemic hyponatremia. Earlier studies showed that patients with moderate liver disease could be safely treated with conivaptan by reducing the dose by 50%, whereas patients w...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Des Devel Ther
Prif Awduron: Marbury, Thomas, Fox, Jerry, Kaelin, Byron, Pavliv, Leo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove Medical Press 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315214/
https://ncbi.nlm.nih.gov/pubmed/28243060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S125459
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