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Pharmacokinetics of conivaptan use in patients with severe hepatic impairment

PURPOSE: Conivaptan is an intravenous dual V(1A)/V(2) vasopressin antagonist approved for the treatment of euvolemic and hypervolemic hyponatremia. Earlier studies showed that patients with moderate liver disease could be safely treated with conivaptan by reducing the dose by 50%, whereas patients w...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Marbury, Thomas, Fox, Jerry, Kaelin, Byron, Pavliv, Leo
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315214/
https://ncbi.nlm.nih.gov/pubmed/28243060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S125459
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